Université PSL

Laboratoire Biologie cellulaire systémique de la polarité et de la division

UMR 144
Our team studies the process of cell polarization, in the context of cell migration and cell division. A cell is polarized when it has developed a main axis of organization. Polarization can occur spontaneously or be triggered by external signals, like gradients of signaling molecules, light, forces or even electrical fields. It involves a reorganization of the cell cytoskeleton and intracellular organelles and eventually results in a specific cell response: directional migration or growth, oriented division, oriented secretion, etc…
We use and develop innovative tools based on micro-fabrication techniques, in order to control the main physical and chemical parameters of the cell micro-environment. These tools are coupled with high quality quantitative microscopy, as well as regular molecular and cell biology techniques, providing a quantitative description of the cell behaviour.
Our current project focus on how physical and geometrical constrains impact cell division and cell migration.
Affiliated institution: Institut Curie
Responsable: Matthieu Piel

Department: Subcellular structure and cellular dynamics - Institut Curie / CNRS UMR 144
Team: Systems Biology of Cell Division and Cell Polarity
26 rue d’Ulm 75248 PARIS CEDEX 05
Fax : +33 (0)1 56 24 63 19

Learn more about this laboratory