Université PSL

Research Projects

L’IPGG offre des financements postdoctoraux pour des projets où la microfluidique joue un rôle central au sein des équipes de recherche membres de l'IPGG.

Nous mettons un accent particulier sur les projets "à haut risque scientifique", ceux qui sont difficiles à financer par les sources habituelles (ANR, etc.).

Nous donnons la possibilité de nous proposer plusieurs thèses pour un seul projet au sein de différents laboratoires de l’IPGG.

Nous souhaitons soutenir un ou deux projets de plus grande ampleur pour lequel, grâce à une synergie mise en œuvre au sein de l’IPGG, il sera possible de relever des défis d’envergure.



Label-free opto-electrochemical imaging in microfluidic devices: from point-of-care diagnosis to the tracking of single nano-objects

Team:
LSABM
​Project leader:
Frédéric Kanoufi
Year:
2013

The objective is to develop “chemical microscopy” in microfluidic systems. It is based on the label-free in situ and real time optical monitoring of chemical transformation of a surface and consists of coupling optical imagery detection to electro- or bio-chemical activation of a surface. The principle and methodology have wide application ranges.
Such label-free detection in microfluidic heterogeneous assays will be developed allowing for :
i) the detection of biomolecular recognition owing to the design of new, fast and cheap label-free point-of-care diagnosis platforms and
ii) the detection of single chemical events illustrated in the optical tracking of the individual catalytic reactivity of single nanoparticles.


Immune system on a chip part I : maturation of denditric cells

Team:
BIO6
​Project leader:
Matthieu Piel, Ana-Maria Lennon-Duménil, Edgar Gomes, Charles BAROUD
Year:
2012

The adaptive immune response, which allows organisms to develop immunity against a priori unknown pathogens, relies on a multimodal system aimed at detecting, delivering and analyzing information from peripheral tissues to trigger a response specific for the pathogen. Detection is performed by dendritic cells, which patrol peripheral tissues and engulf large amounts of material. This material is then processed and presented at their cell surface. Upon exogeneous or endogeneous triggers called ‘danger signals’, dendritic cells migrate towards lymph vessels and reach draining lymph nodes where they activate T lymphocytes, an essential step for the onset of the specific immune responses. Because it is very difficult to follow single dendritic cells and T lymphocytes through their journey inside the body, the adaptive immune response is often studied at steady state, on large populations of cells extracted at various points from different organs.


Digitalized electrokinetic separation for biomarker analysis

Team:
MMBM
​Project leader:
Stéphanie Descroix, Laurent Malaquin, Jean-Louis Viovy
Year:
2012

The development of original methods dedicated to biomarkers quantitation to improve current medical diagnosis is still challenging. The aim of this project is to develop an integrated platform able to perform multimodal biomarker analysis at ultrasensitive levels. In particular, the system will integrate a high resolution electrophoresis combined with a compartmentalization by biphasic microfluidics. This compartmentalization will allow their further quantitation through a droplet based immunoassay. This project will be validated on the early detection of biomarkers for neurodegenerative diseases, notably Alzheimer.


Ultrafast acoustic micromixer and applications

Team:
MMN
​Project leader:
Patrick Tabeling
Year:
2012

A multidisciplinary team of experts in acoustics (M. Tanter, O.Couture), microfluidics (P. Tabeling, F. Monti), and organic chemistry (J. Cossy, S. Arseniyadis), pool their efforts to invent a method for in-vitro (in microfluidic systems) and in-vivo high-speed micro-mixing of reagents. The method consists in dispersing the reactants in submicron droplets, then encapsulated in perfluorocarbon bigger droplets. Then, applying a focused ultrasonic wave vaporizes the perfluorocarbon, and expels, in a few microseconds, the reagents to the external phase where they can mix, under isothermal conditions. We think we can mix reagents on less than 100 microseconds time scales, and win one or two orders of magnitude compared to the fastest methods of micromixture reported in the literature. This is a great breakthrough, establishing a new generation of micro-mixers. There are many applications: in-vivo delivery of drugs and prodrugs, measurement of chemical kinetics, dynamic conformational analysis, etc. In this project, we focus on applications in the field of in-vivo delivery of drugs and prodrugs.


Thermo-actuated migration in a microystem, application to foam drainage control

Team:
MMN
​Project leader:
Marie-Caroline Jullien et Florent Malloggi
Year:
2012

We have recently shown that when a bubble or a drop is submitted to a temperature gradient, it migrates to the coldest region by a mechanical effect, i.e. the deformation of the PDMS causes the element to move to the area where the cavity is the thickest. We have identified some mechanisms involved in this system. We first want to make a general mapping of the response of the bubble/drop depending on different control parameters. We believe that this study may be used for future reference.


Development of a lab-on-chip device for the analysis, treatment and recycling of pharmaceuticals at trace levels water samples

Team:
SEISAD
​Project leader:
Anne Varenne, Fanny d’Orlyé, Fethi Bedioui et Sophie Griveau
Year:
2012

Developed to promote human health and well being, certain pharmaceuticals are now attracting attention as crucial emerging water contaminants. To deal with this concern, we aim to develop an analytical microsystem that allows selective extraction of targeted pharmaceuticals and their metabolites for the identification and quantification of these contaminants in water samples. The selectivity and sensitivity of this lab-on-chip rest on the implementation of an aptamer-based molecular capture. This will be achieved in a confined zone of the separation channel through an electrochemically induced micro-scale functionalization of its surface. Fluorescent or electrochemical detection systems will be considered as they can be easily integrated in a miniaturized system while offering high selectivity and sensitivity. Eventually, this analytical microsystem will be designed so as to be hyphenated to a miniaturized processing platform either for on-line water purification (ozone oxidation process) or for on-line recovery and recycling of the waste pharmaceuticals.


36 projects.